Samuel Clark Aiken (September 21, 1791 – January 1, 1879) was a prominent American Presbyterian minister and the first resident pastor of First Presbyterian (Old Stone) Church in Cleveland, leading the congregation from 1835 to 1861 and guiding it through major theological and social challenges of the mid-19th century. Born in Windham, Vermont, and educated at Middlebury College and Andover Theological Seminary, he was ordained in 1818 in Utica, New York, and later became a leading voice in Cleveland civic life, presiding over the organizational meeting of the local YMCA and speaking publicly on public improvements, temperance, and other reforms. Aiken’s long and influential ministry left a durable imprint on both the church and community, and he is remembered as one of Cleveland’s most important clergymen of his era.